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what is the function of apoptosis and p53?

what is the function of apoptosis and p53? - Apoptosis, Autophagy, and Necrosis Forum

what is the function of apoptosis and p53? - Discuss and post questions about Apoptosis, Programmed Cell Death, Necrosis, Autophagy, and other forms of cell death.


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Old 01-07-2014, 01:46 PM
Pipette Filler
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Default what is the function of apoptosis and p53?



i cant manage to tell the difference


and where does apoptosis occurs in nature
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Old 01-07-2014, 01:47 PM
Pipette Filler
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p53 makes sure that there are no serious mutations in the cell. If there are mutations the cell will undergo apoptosis. This protects the rest of the organism, because cells from mutations can become cancer cells. Imagine someone in the zombie apocalypse shooting themselves after their bitten so they don't turn into a zombie and kill all their family.

Apoptosis also occurs a lot during embryonic development because there are a lot of structures that form that need to be gotten rid of later. For example, when your fingers form, they are webbed, but apoptosis occurs and the webbing between your fingers die so that you don't have webbed fingers when you're born. You also have a tail when you develop in the womb but that dies too.
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Old 01-07-2014, 01:47 PM
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Apoptosis occurs in a growing fetus. The fetus, when developing limbs, for example, has webbed fingers at first. If you look at your fingers now there are clearly spaces between them. This was not the case in the womb. Specific cells were signaled to undergo apoptosis to form the gaps between our fingers. Same with our toes and our tails in the womb. Do not confuse apoptosis with cytolysis. (apoptosis = cell "suicide", cytolysis = cell "exploding" due to excess of water, for example.)

p53 is a protein that, in humans, is encoded by the TP53 gene. The p53 protein is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressor, preventing cancer.

Apoptosis is the absolute end of a living cell's cycle and p53 is a protein regulating the cell cycle. (p53 activates apoptosis)
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Old 01-07-2014, 01:47 PM
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Apoptosis occurs everywhere in nature all of the time. Cells that grow old need to die if they begin to function improperly. Cells during development of a fetus need to die in certain places to form spaces, like between fingers, toes, legs, because we all start out as just a blob, a clump of cells.

If a cell doesn't pass one of the cell cycle checkpoints, it performs apoptosis, which is programmed cell death. P53 is a tumor suppressor protein that CAUSES apoptosis if it determines the cell is performing irregularly at the mitotic spindle checkpoint. So p53 will tell the cell to kill itself to avoid faulty replication (which leads to the creation and proliferation of a tumor) if it determines the cell is not functioning properly and is unfixable.
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