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-   Apoptosis, Autophagy, and Necrosis Forum (http://www.molecularstation.com/forum/apoptosis-autophagy-necrosis-forum/)
-   -   How does bcl-xl inhibit apoptosis? (http://www.molecularstation.com/forum/apoptosis-autophagy-necrosis-forum/87852-how-does-bcl-xl-inhibit-apoptosis.html)

Kevon S 05-05-2013 11:18 PM

How does bcl-xl inhibit apoptosis?
 
Im doing a project on bcl-xl but I dont know the exact cellular process of how it stops apoptosis in cells

Caroline Miller 05-05-2013 11:18 PM

"anti-apoptotic molecules, BCL-XL... have been reported to bind Apaf-1 (apoptotic protease-activating factor-1)"
it is also thought to inhibit the release of cytochrome c and alter the mitochondrial membrane potential. it may alter or form ion channels in the mitochondrial membrane.
"regulate the mitochondrial pathway of apoptosis by controlling the permeabilization of the outer mitochondrial membrane."


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