| | Re: Apoptosis in Renal damage
there is a new type of cell death----necroptosis, which was dicovered by Junying Yuan.
A new pathway to necrosis, a form of cell death, is described in July's Nature Chemical Biology. Necrosis is a common feature of human pathologies from stroke to neurodegeneration and unlike apoptosis -- a precisely orchestrated cellular pathway to initiate death -- was generally believed to be a passive cellular response to external damage. Junying Yuan and colleagues identify a previously unknown cellular pathway leading to necrosis, which they call necroptosis. The team demonstrate its involvement in conditions where not enough blood reaches the brain -- otherwise known as ischemic brain injury.
A growing number of studies have reported evidence for non-apoptotic cell death with some features of necrosis. However, scientists have had no tools to investigate the potential mechanisms behind these observations. To address this, Yuan and colleagues identified a chemical, necrostatin-1, which specifically inhibited this non-apoptotic cell death. They found that necrostatin-1 blocked all cases of this cell death, demonstrating the existence of a specific cellular pathway, necroptosis, leading to necrosis. They further showed that necrostatin-1 reduced ischemic brain injury in a mouse model of stroke, establishing a causal role of necroptosis in ischemic trauma-induced neuronal damage. Necrostatin-1 is a promising therapeutic lead for treating patients with brain injury following stroke.
In addition to its therapeutic potential, necrostatin-1 provides an important new chemical tool for investigating the precise molecular mechanism of necroptosis and the role of this pathway in other pathologies involving necrosis.