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How is it, that TNF's are tumour necrosis factors, yet

How is it, that TNF's are tumour necrosis factors, yet - Apoptosis, Autophagy, and Necrosis Forum

How is it, that TNF's are tumour necrosis factors, yet - Discuss and post questions about Apoptosis, Programmed Cell Death, Necrosis, Autophagy, and other forms of cell death.


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Old 03-18-2007, 04:05 AM
Pipette Filler
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Default How is it, that TNF's are tumour necrosis factors, yet



they are involved in apoptosis and cause apoptosis? Shouldn't Tumour Necrosis Factors cause Necrosis, rather than apoptosis...
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Old 03-18-2007, 04:20 AM
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The same way as you use a bat to play as well as to hit .
We can not force a molecule to do only one job,it is only that we came to know about their various functions.Again nature tries to get lots of things done by a single molecule to minimise expences of energy and matter.
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Old 03-18-2007, 05:08 AM
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Both necrosis & apoptosis lead to imminent cell death, so it may be a distinction without a difference.
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Old 03-18-2007, 05:31 AM
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TNF was named prior to the major work done on apoptosis- The terms refers to the fact that TNF caused necrosis of the tumor, in the days when necrosis just meant death. That being said, TNFa has a very large number of functions, including activation of the immune system. In addition, TNFa is actually a survival factor for many neuronal cells. In death pathways, TNF can stimulate classic caspase-mediated apoptosis, mitochondrial-mediated non-caspace programmed cell death, and necrosis, depending on the cell, the presence of other mediating signal molecules, and the energy state of the cell. The old rule"one protein, one function" is a hopelessly obsolete concept.
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