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Thalassemia treated in mice with Morpholino

Thalassemia treated in mice with Morpholino - Animal and Molecular Model Systems

Thalassemia treated in mice with Morpholino - Discuss and Post Questions about Animal Model Systems such as Mouse, Rat, Pig, Sheep etc.


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Old 02-04-2009, 04:27 PM
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Default Thalassemia treated in mice with Morpholino



Morpholinos conjugated with cell-penetrating peptides were injected into mice carrying a splice-site mutation in beta-globin. The Morpholinos blocked the mutant splice sites and restored normal splicing so that the mice produced fully-functional hemoglobin.

Svasti S, Suwanmanee T, Fucharoen S, Moulton HM, Nelson MH, Maeda N, Smithies O, Kole R. [Only registered users see links. ] Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1205-10. Epub 2009 Jan 21.

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Old 02-05-2009, 05:00 AM
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Default Re: Thalassemia treated in mice with Morpholino

thanks for sharing Jon
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mice , morpholino , mouse , mutant , splice , thalassemia , treated


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