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Myotonic dystrophy mice and splice blocking

Myotonic dystrophy mice and splice blocking - Animal and Molecular Model Systems

Myotonic dystrophy mice and splice blocking - Discuss and Post Questions about Animal Model Systems such as Mouse, Rat, Pig, Sheep etc.


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Old 11-16-2007, 08:49 PM
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Default Myotonic dystrophy mice and splice blocking



Morpholinos targeting exon 7a of the muscle-specific chloride channel 1 (ClC-1) relieved symptoms of myotonic dystrophy type 1 in two mouse models.

Wheeler TM, Lueck JD, Swanson MS, Dirkson RT, Thornton CA. Correction of CIC-1 splicing eliminates chloride channelopathy and myotonia in mouse models of myotonic dystrophy. JCI 2007 doi:10.1172/JCI33355
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Old 01-24-2008, 05:04 PM
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Default Re: Myotonic dystrophy mice and splice blocking

Thanks.
Very interesting paper.
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blocking , dystrophy , mice , myotonic , splice


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