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Myotonic dystrophy mice and splice blocking
Animal and Molecular Model Systems
Discuss and Post Questions about Animal Model Systems such as Mouse, Rat, Pig, Sheep etc.
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11-16-2007, 07:49 PM
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 Myotonic dystrophy mice and splice blocking Morpholinos targeting exon 7a of the muscle-specific chloride channel 1 (ClC-1) relieved symptoms of myotonic dystrophy type 1 in two mouse models. Wheeler TM, Lueck JD, Swanson MS, Dirkson RT, Thornton CA. Correction of CIC-1 splicing eliminates chloride channelopathy and myotonia in mouse models of myotonic dystrophy. JCI 2007 doi:10.1172/JCI33355        |
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