Xenotransplanted primordial germ cells make viable gametes (paper) Primordial germ cells (PGC) transplanted across species, even across genera, into zebrafish with host PGC inactivated by Dead End Morpholinos produced offspring from daughter cells of the transplanted PGC after natural spawning:
Saito T, Goto-Kazeto R, Arai K, Yamaha E. Xenogenesis in Teleost Fish Through Generation of Germ-Line Chimeras by Single Primordial Germ Cell Transplantation. Biol Reprod. 2007 Sep 26; [Epub ahead of print] |