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Motor Protein That Rewinds DNA

Two biologists at the University of California, San Diego have discovered the first of a new class of cellular motor proteins that ?rewind? sections of the double-stranded DNA molecule that become unwound, like the tangled ribbons from a cassette tape, in ?bubbles? that prevent critical genes from being expressed. ?When your DNA gets stuck in [...]

Histone Deacetylase Inhibitors Eliminate Cocaine Sensitization

In the nucleus, DNA wraps around histone proteins, which pack the DNA and makes it less accessible for transcription. Many transcriptional activators promote histone acetylation, which opens the chromatin structure and helps recruit transcription machinery to the newly accessible genes. Conversely, some gene repressors promote deacetylation of histones. Because drug dependence is mediated partly by [...]

Genetic Maps of Pancreatic Cancer and Brain Cancer Completed

The complete genetic blueprint for lethal pancreatic cancer and brain cancer was deciphered by a team at the Johns Hopkins Kimmel Cancer Center. The studies, led by the same group who completed maps of the breast cancer and colorectal cancer genomes in 2007, are reported in two articles in the Sept. 5, 2008, issue of [...]

Woolly Mammoth DNA

In a surprising reversal of conventional wisdom, a DNA-based study has revealed that the last of the woolly mammoths?which lived between 40,000 and 4,000 years ago?had roots that were exclusively North American.The research, which appears in the September issue of Current Biology, is expected to cause some controversy within the paleontological community. “Scientists have always [...]

Junk DNA HACNS1 Discovery

Out of the 3 billion genetic letters that spell out the human genome, Yale scientists have found a handful that may have contributed to the evolutionary changes in human limbs that enabled us to manipulate tools and walk upright. Results from a comparative analysis of the human, chimpanzee, rhesus macaque and other genomes reported in [...]

New Ways to Regulate Genes Reduce Heart Damage

Researchers at the University of Cincinnati (UC) are looking for ways to reduce or prevent heart damage by starting where the problem often begins: in the genes. Following a heart attack, cells die, causing lasting damage to the heart. Keith Jones, PhD, a researcher in the department of pharmacology and cell biophysics, and colleagues are [...]

DNA Repair Visualized in Real Time

For the first time, researchers at Delft University of Technology have witnessed the spontaneous repair of damage to DNA molecules in real time. They observed this at the level of a single DNA molecule. Insight into this type of repair mechanism is essential as errors in this process can lead to the development of cancerous [...]

Electron Microscopy Imaging Technique Reveals Sharper Images of Chromatin

University of Illinois researchers have developed a technique for imaging cells under an electron microscope that yields a sharper image of the structure of chromatin, the tightly wound bundle of genetic material and proteins that makes up the chromosomes. The findings appeared in Nature Methods. Scientists have known for more than a century that proteins, [...]

High Throughput Analysis of the Epigenome

(LA JOLLA, CA) Salk researchers zoom in on genome-wide DNA methylation and transcriptomes at single base resolution. Until quite recently, the chemical marks littering the DNA inside our cells like trees dotting a landscape could only be studied one gene at a time. But new high-throughput DNA sequencing technology has enabled researchers at the Salk [...]

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DNA Forum Topics

forum Plasmid PCR question... I am a biochemist working with a bunch of physicists, and an interesting point came up the other day while discussing PCR in plasmids. At the end...
forum DNA silverstaining Does anbody know about the logic behind the DNA silverstaining? For example Why the band develop in developer?what kind of chemical reactions happen...
forum Can I trust my QPCR data? Hi all I am fairly new to the technique quantitative RT-PCR so I have a question I hope you guys can help me with. In my experiments I have...
forum ChIP buffer Hi, I was wondering if anybody knows the composition of the Cell and Nuclear Lysis buffer from Millipore Magna ChIP kit . That would help me a lot!...
forum DNA/Chromosome Identification? Anyone know if the following letters have anything to do with a dna or chromosome number/identifier? o a n q
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