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But as for certain truth, no man has known it, Nor will he know it; neither of the gods, Nor yet of all the things of which I speak. Men da der for visse sandheden, ingen mand har vidst det, heller ikke vil han vide det; ingen af de guder, heller ikke af alle de ting, som jeg taler. And even if by chance he were to utter The final truth, he would himself not know it; For all is but a woven web of guesses. Og selvom tilfældigt, at han skulle fremsige Den endelige sandhed, ville han selv ikke vide det, for alle er, men et vævet spind af gætter. ~Xenophanes (c. 570-c. 480 BCE) Greek philosopher. ~ Xenofanes (c. 570-c. 480 BCE) græsk filosof.
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Recently there has been an explosion of peptide utilization in all science fields, thus the growing demand for the synthesis of synthetic peptides. Peptide have been proved to act as great probes for the study of protein-protein interactions, the binding of ligands to the extracellular domains of cell surface proteins and receptors, studying epitopes in immunology or antibody-antigen interactions, the study of inhibitory peptides on protein functions such as inhibition of cancer-inducing proteins, and enzyme-protein substrate interactions to mention a few. Also the design and application of fluorescent substrate-based peptides can be used to determine the selectivity and activity of peptidases. For nylig har der været en eksplosion af peptid udnyttelse inden for alle videnskabelige områder, således det voksende behov for syntese af syntetiske peptider. Peptide har vist sig at handle lige så stor sonder til studiet af protein-protein interaktioner, vil bindingen af ligands til ekstracellulære domæner af celle overflade proteiner og receptorer, studerer epitoper i immunologi eller antistof-antigen interaktion, undersøgelse af hæmmende peptider på protein funktioner såsom hæmning af kræft-overtalelse proteiner, og enzym-protein interaktioner substrat at nævne et par stykker. Også design og Anvendelsen af fluorescerende substrat-baserede peptider kan anvendes til at bestemme selektivitet og aktivitet af peptidaser.
Synthetic peptides can be utilized as probes in all the previously mentioned scenarios as they all involve amino acid residue interactions . Syntetiske peptider kan udnyttes som sonder i alle de tidligere nævnte scenarier som de alle involverer aminosyre rest interaktioner. Although many of these protein interactions often involve amino acid residues from distant protein domains, there are many examples where short stretches of amino acids are vital for protein-protein interactions (acting as contiguous epitopes) and thus allow the application and the use of synthetic peptides for the study of a broad range of biological phenomena. Selv om mange af disse protein interaktioner ofte involvere aminosyre rester fra fjerntliggende protein domæner, der er mange eksempler, hvor korte strækninger af aminosyrer er af afgørende betydning for protein-protein interaktioner (der optræder som sammenhængende epitoper) og således tillade anvendelsen og brugen af syntetiske peptider til undersøgelse af en bred vifte af biologiske fænomener.
The creation of antibodies specific for a protein is quickly done using peptides. Oprettelsen af antistoffer specifikke for et protein er hurtigt gjort ved hjælp af peptider. Peptides will not fold similarly to native proteins (due to their smaller size and lack of many native residues), however they can be useful in the generation of antibodies. Peptider vil ikke fold lighed med native proteiner (på grund af deres størrelse og mangel på mange indfødte restkoncentrationer), men de kan være nyttige i den generation af antistoffer.
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