Intracellular StationsAntibodyBotany Chemistry Common Buffers Buffers Alphabetic Bookstore Cell Biology and Culture Gel Electrophoresis Histology Microarrays Immunology Mass Spectrometry Microbiology Molecular Imaging Peptide Protein Microarray Chips PCR Real-Time PCR RNAi and SiRNA Stem Cell Biology Transfection Western Blot |
User PanelMy PanelMy PanelBookmark Science Articles
|
||||
At Molecular Station Bioinformatics, you will find all the bioinformatics programs you will need. We have over 800 bioinformatic tools for DNA bioinformatics, RNA bioinformatics, Protein Bioinformatics, and Proteomic bioinformatic tools. We also provide databses for each of these categories in order to easily find your sequence of interest from several sequence databases.
Our Bioinformatic tools database has all the bioinformatic tools you will ever need and includes online programs and tools on:
Subcellular localization of marine bacterial alkaline phosphatases.
Proc Natl Acad Sci U S A. 2009 Nov 19;
Authors: Luo H, Benner R, Long RA, Hu J
Bacterial alkaline phosphatases (APases) are important enzymes in organophosphate utilization in the ocean. The subcellular localization of APases has significant ecological implications for marine biota but is largely unknown. The extensive metagenomic sequence databases from the Global Ocean Sampling Expedition provide an opportunity to address this question. A bioinformatics pipeline was developed to identify marine bacterial APases from the metagenomic databases, and a consensus classification algorithm was designed to predict their subcellular localizations. We identified 3,733 bacterial APase sequences (including PhoA, PhoD, and PhoX) and found that cytoplasmic (41%) and extracellular (30%) APases exceed their periplasmic (17%), outer membrane (12%), and inner membrane (0.9%) counterparts. The unexpectedly high abundance of cytoplasmic APases suggests that the transport and intracellular hydrolysis of small organophosphate molecules is an important mechanism for bacterial acquisition of phosphorus (P) in the surface ocean. On average, each marine bacterium possessed at least one suite of uptake of glycerol phosphate (ugp) genes (e.g., ugpA, ugpB, ugpC, ugpE) for dissolved organic phosphorus (DOP) transport, but only half of them had ugpQ, which hydrolyzes transported DOP, indicating that cytoplasmic APases play a role in hydrolyzing transported DOP. The most abundant heterotrophic marine bacteria, alpha- and gamma-Proteobacteria, might hydrolyze DOP outside the cytoplasmic membrane, but the former could also transport and hydrolyze DOP in the cytoplasm. The abundant extracellular APases could provide bioavailable P for organisms that cannot directly access organophosphates, and thereby increase marine biological productivity and diversity.
PMID: 19926862 [PubMed - as supplied by publisher]
Findings in Early TB Infection
New Genetic Evidence for First Americans
Reduced Colorectral Cancer Risk With Hormone Therapy
Childhood Trauma Connection and Risk for Chronic Fatigue Syndrome
Dual Role Gene Plays Part in Breast Cancers with Poor Prognosis
Insight Into Aggressive Childhood Cancer
New Genetic Markers for Ulcerative Colitis
Novel Glioblastoma Mouse Model
New Way To Fuse Cells
Aquaculture Growth ContinuingFor more click here:Science News
![[أربيك]](http://www.molecularstation.com/translate/images/flag_ar.gif){kind=small}
